Original Articles, Reviews, and Letters

Freese, A. (1999): Restorative Gene Therapy Approaches to Parkinson’s Disease, Medical Clinics of North America, 83:537-48.

Freese, A., Simeone, F.A. (1999): Treatment of Neurosurgical Disease in the New Millenium, Ophthalmology Clinics of North America, 12(4):533-537.

Leone, P., McPhee, S.W., Janson, C.G., Liu, C., Silver, D., Davidson, B.L., Freese, A., During, M.J. (2000): Multi-site Partitioned Delivery of Human Tyrosine Hydroxylase Gene with Phenotypic Recovery in Parkinsonian rats, Neuroreport, 11(6):1145-51.

Leone, P., Janson, C.G., Bilianuk L., Wang, J., Sorgi, F., McPhee, S.W., Haung, L., Matalon, R., Kaul, R., Freese, A., Young, D., Xu, R., Mee, E., During, M.J. (2000): Apartoacylase Gene Transfer to the Mammalian Nervous System with Therapeutic Implications for Canavan Disease, Annals of Neurology, 48:27-38.

Janson, C.G., McPhee, S., Leone, P., Freese, A., During, M.J. (2001): Recombinant Viral-Based Gene Transfer to the Mammalian CNS for Functional Genomic Studies, Trends in  Neuroscience, 24(12): 706-712.

Janson, C.G., McPhee, S., Bilaniuk, L., Haselgrove, J., Testaiuti, M., Freese, A., Wang, D-J., Shera, D., Hurh, P., Rupin, J., Saslow, E., Goldfarb, O., Goldberg, M., Larijani, G., Sharrar, W., Liouterman, L., Camp, A., Kolodny, E., Samulski, R.J., Leone, P. (2002): Gene Therapy of Canavan Disease: AAV-2 Vector for Neurosurgical Delivery of Aspartoacylase Gene (ASPA) to the Human Brain, Human Gene Therapy, 13:1391-1412.

Janson C.G., Leone, P., Freese, A. (2002): Parkinson’s Disease: Molecular Pathology,  Science and Medicine, 8:328-337.

Janson C.G., Leone, P., Freese, A. (2003): Parkinson’s Disease: Cellular Basis of Medical TreatmentScience and Medicine, 9:24-35.

Janson C.G., Leone, P., Freese, A. (2003): Parkinson’s Disease: Surgical and Emerging Therapies, Science and Medicine, 9:82-95

Harrop, J.S., Poulsen, D., Xiao W., Freese, A., During, M.J. (2004): Effect of Altering Titer, Serotype, and Promoter in Recombinant Adenoassociated Virus Gene Therapy Expression of Spinal Cord Neurons and Astrocytes. Spine, 29(24):2787-2792.

McPhee, S., Francis, J., Janson, C.G., Serikawa, T., Hyland, K., Ong, E., Raghavan, S., Young, D., During, M.J., Freese, A., Leone, P. (2005): Effects of AAV-2 mediated aspartoacylase gene transfer in the tremor rat model of Canavan Disease, Molecular Brain Research, 135(1-2):112-121.

Freese, A., Janson, C., Leone, P., Simeone, F.A. (2005): Introduction to Principles of Molecular Neurosurgery, Prog. Neurol. Surg. 18:1-4.

Ohlfest, J., Demorest, Z., Motooka, Y., Oh, S., Chen, E., Scappaticci, F., Ekker, S., Low, W., Freese, A., Largaespada, D. (2005): Combinatorial Antiangiogenic Gene Therapy Causes Tumor Regression and Improves Survival in Mice Bearing Intracranial Human Glioblastoma by Nonviral Gene transfer Using the Sleeping Beauty Transposon, Molecular Therapy, 12(5):778-787.

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