Original Articles, Reviews, and Letters

McPhee, S., Francis, J., Janson, C.G., Serikawa, T., Hyland, K., Ong, E., Raghavan, S., Young, D., During, M.J., Freese, A. , Leone, P. (2005): Effects of AAV-2 mediated aspartoacylase gene transfer in the tremor rat model of Canavan Disease, Mol. Brain Res., 135:112-121.

Wiesner, S.M., Freese, A., Ohlfest, J.R. (2005): Emerging Concepts in Glioma Biology: Implications for Clinical Protocols and Rational Treatment Strategies. Neurosurg. Foc. 19(4): 1-6.

Ohlfest, J., Freese, A.,  Largaespada, D. (2005): Nonviral Vectors for Cancer Gene Therapy, Current Gene Therapy, Curr. Gene Ther. 5:629-641.

Ohlfest, J., Oh, W., Demorest, Z.L., Motooka, Y., Lobitz, P.D., Low, W.C., Largaespada, D.A., Freese, A. (2006): The Sleeping Beauty Transposon Facilitates Sustained Gene Transfer and Expression in Neural Progenitor-like Cells in the Adult Mouse Brain, Molecular Therapy

McPhee, S., Janson, C., Li, C., Samulski, R.J., Camp, A., Shera, F., Lioutermann, L., Feely, M., Freese, A., Leone, P. (2006): Immune Responses to AAV in a Phase 1 Study for Canavan Disease. J. Gene Med. 8(5):577-588.

Janson, C., Freese, A., Mcphee, S., Leone, P. et al. (2006): Natural histor of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion weighted MRI. Neuropediatrics, 37(4):209-221.

Janson, C., Kolodny, E., Zeng, B-J., Raghaven, S., Pastores, G., Torres, P., Assadi, M., McPhee, S., Goldfarb, O., Saslow, B., Freese, A., Wang, D., Bilaniuk, L., Shera, D., Leone, P., (2006): Mild-onset Presentation of Canavan’s Disease Associated with Novel G212A Point Mutation in Aspartoacylase Gene. Annals of Neurology 59:(2):428-431.

Candolfi, M., Kroeger, K.M., Pluhar, G.E., Bergeron, J., Puntel, M., Curtin, J.F., McNeil, E.A., Freese, A.B., Ohlfest, J.R., Moore, P., Lowenstein, P.R., Castro, M.G. (2007): Adenoviral-mediated gene transfer into the canine brain in vivo, Neurosurgery; 60(1):167-178.

Oh, S., Pluhar, G.E., McNeil, E.A., Kroeger, K.M., Liu, C., Castro, M.G., Lowenstein, P.R., Freese, A., Ohlfest, J.R. (2007): Efficacy of Nonviral Gene Transfer in the Canine Brain. J. Neurosurg 107:136-144.

Oh, S., Odland, R., Wilson, S., Kroeger, K.M., Liu, C., Castor, M.G., Lowenstein, P.R., Freese, A., Hall, W.A., Ohlfest, J.R. (2007): Improved Distribution of Small Molecules and Viral Vectors in the Murine Brain Using a Hollow Fiber Catheter. J. Neurosurg. 107(3):568-577.

Candolfi, M., Curtin, J.F., Nichols, W.S., Muhammad, G., King, G., Pluhar, G.E., McNeil, E.A., Ohlfest, J.R., Freese, A.B., Moore, P.F., Lerner, J., Lowenstein, P., Castro, M.G. (2007) Intracranial Glioblastoma Models in Preclinical Neuro-Oncology: Neuropathological Characterization and Tumor Progression. J. Neurooncol. 85(2):133-148.

Candolfi, M., Pluhar, G.E., Kroeger, K., Puntel, M., Curtin, J., Barcia, C., Muhammad, G., Xiong, W., Liu, C., Mondkar, S., Kuoy, W., Kang, T., McNeil, E.A., Freese, A.B., Ohlfest, J.R., Moore, P., Palmer, D., Ng, P., Young, J.D., Lowenstein, P.R., Castro, M.G. (2007): Optimization of Adenoviral Vector-mediated Transgene Expression in the Canine Brain In Vivo, and in Canine Glioma Cells In Vitro. Neuro-oncology 9:245-258.

Leone, P., Shera, D., McPhee, S.W.J., Francis, J.S., Kolodny, E.H., Bilaniuk, L.T., Wang, D-Y., Assadi, M., Goldfarb, O., Goldman, H.W., Freese, A., Young, D., During, M.J., Samulski, R.J., Janson, C.G. (2012): Long-Term Follow-Up After Gene Therapy for Canavan Disease. Science Translational Medicine 165ra163:1-14.

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